PATHOL 750 “General Pathology”, Spring Semester 2020
MWF, 3:20 to 4:10 p.m, via Zoom
Course Director: Laura P. Hale, M.D. Ph.D. (919) 684-4771 laura.hale@duke.edu
Teaching Assistant: Amelia Schirmer (910) 528-5661 amelia.schirmer@duke.edu

 

 Day

 Date

 Topic

 Assignment due BEFORE Class

Wed Jan 20 Cellular Adaptation, Injury, & Death I Ch 1,2
Fri Jan 22 Cellular Adaptation, Injury, & Death II View lecture recording; take quiz

Mon

Jan 25

Cellular Adaptation, Injury, & Death III

Submit slide description ppt

Wed

Jan 27

Inflammation and Tissue Repair I

Read Ch 3

Fri

Jan 29

Inflammation and Tissue Repair II

View lecture recording; take quiz

Mon

Feb 1

Inflammation and Tissue Repair III

Submit slide description ppt

Wed

Feb 3

Hemodynamic Disorders I

Ch 4, 11*, 12*

Fri

Feb 5

Hemodynamic Disorders II

View lecture recording; take quiz

Mon

Feb 8

Hemodynamic Disorders III

Submit slide description ppt

Wed

Feb 10

Review

--

Fri

Feb 12

Review

--

Mon

Feb 15

Exam 1

--

Wed

Feb 17

Pathology of Infectious Disease I

Ch 8

Fri

Feb 19

Pathology of Infectious Disease II

View lecture recording; take quiz

Mon

Feb 22

Pathology of Infectious Disease III

Submit slide description ppt

Wed

Feb 24

Immunopathology I

Ch 6

Fri

Feb 26

Immunopathology II

View lecture recording; take quiz

Mon

Mar 1

Immunopathology III

Submit slide description ppt

Wed

Mar 3

Neoplasia I

Ch 7

Fri

Mar 5

Neoplasia II

View lecture recording; take quiz

Mon

Mar 8

Neoplasia III

Submit slide description ppt

Wed

Mar 10

NO CLASS - Mini Spring Break

--

Fri

Mar 12

Review

--

Mon

Mar 15

Exam 2

--

Wed

Mar 17

Environmental & Nutritional Pathology I

Ch 9

Fri

Mar 19

Environmental & Nutritional Pathology II

View lecture recording; take quiz

Mon

Mar 22

Genetic & Developmental Disorders I

Ch 5, 10*

Wed

Mar 24

Genetic & Developmental Disorders II

View lecture recording; take quiz

Fri

Mar 26

Genetic & Developmental Disorders III

Submit slide description ppt

Mon

Mar 29

Endocrine Disorders

Ch 24

Wed

Mar 31

Review

View lecture recording; take quiz

Fri

Apr 2

Review

--

Mon

Apr 5

Exam 3

--

Wed

Apr 7

Student Presentations

--

Fri

Apr 9

Student Presentations

--

Mon

Apr 12

NO CLASS - Wellness Day

--

Wed

Apr 14

Student Presentations

--

Fri

Apr 16

Student Presentations/Review

--

Mon

Apr 19

Review for Slide Practical

--

Wed

Apr 21

Review for Slide Practical

Take mock slide practical (not graded)

Fri

Apr 23

Slide Practical Exam

--


Assigned Reading: To make the most of our in-person sessions, we ask that you try to read or at least page through the assigned reading BEFORE the first class of each unit, to familiarize yourself with the topics to be covered. The primary text is Robbins and Cotran Pathologic Basis of Disease. There are currently 2 available editions: 9th Edition, by V. Kumar, A.K. Abbas, and J.C. Aster. Saunders Elsevier, Philadelphia, 2015 (~$70 from various on-line sources) and the 10th edition by V. Kumar, A.K. Abbas, and J.C. Aster. Saunders Elsevier, Philadelphia, 2021 (~$120 from amazon.com). Either edition is acceptable. For free electronic access to the 10th Edition, go to the Medical Center Library website ( http://mclibrary.duke.edu) from a Duke IP address. Select the heading "EBOOKS", and search for the title “Pathologic Basis of Disease”. We will be going through the “General Pathology” section (Chapters 1 – 10) of this book in great detail to learn basic pathologic processes.

The remaining chapters are organized into “Diseases of Organ Systems”, where manifestations of the various basic pathologic processes in various organ systems are described in greater detail. Portions of some of these additional chapters will also be required reading. The chapters that are not required may also be helpful for class and/or your research.

Recorded Lectures and Quizzes: In previous years, this class met for 90 minutes/class session to provide adequate time for both lecture and laboratory. However, this year, our live virtual class meetings are restricted to 50 minutes. To make the best use of this limited “face time”, we will trying some new things. Most units have 3 class meetings. On the first meeting, we will outline some basic concepts of the unit as well as giving live examples of the specific pathologic processes to be covered. The remainder of the important material for that unit will be recorded for you to watch before the next class session. A short, open book, open note quiz testing your understanding of these concepts will be due prior to the 2nd class session of the unit. The second class session will be devoted primarily to a virtual microscopy laboratory session, with sharing of specific virtual slides that students find problematic. On the third class session, instructors will lead discussions based on commonly encountered research problems that require an understanding of the pathologic mechanisms presented in that unit. Students should also be prepared to present their slide description powerpoints (see below) to the class as time permits.

Exams: Exams will be combinations of questions or problems that illustrate and synthesize the main topics studied to date, as well as identification of pathologic processes exhibited in gross and/or microscopic images. For the images and on the slide practical, you will be expected to be able to identify the organs involved as well as the category of pathologic process that is demonstrated (e.g. inflammatory/infectious/immunologic, hemodynamic/vascular, benign vs. malignant neoplasia, genetic/developmental, or environmental/nutritional). In some cases, you will also be expected to provide a diagnosis (i.e. acute inflammation in the lungs is called
 pneumonia).

Presentation: This is a 20-minute oral presentation on the pathophysiology of a disease of your choice. The topic must be pre-approved by the course director. You should not present about a disease that is part of your graduate research or one that we will be covering in class. In addition to the oral presentation, you must also provide a (no more than) 2 page handout summarizing the important points of your presentation. The handout should not just be a copy of your PowerPoint slides! Rather, it should help your classmates remember the important points about the disease that you are discussing. The references used to prepare your presentation should also be provided and are not part of the 2 page limit. To get into the habit of proper attribution, any slides that contain figures that you did not assemble yourself (i.e. they were derived from a paper or from the web) should also be referenced. The proper way to reference a web site is to give the URL and the access date.

Slide Description Powerpoints: For most units, each student will be assigned a virtual slide to describe. Descriptions should include a low-to-medium magnification photo of the piece of tissue with important features annotated, as well as higher magnification images as needed to demonstrate the pathologic changes. These descriptions will be submitted in the form of a Powerpoint file. The expected number of slides in the ppt file is 3-5; the maximum is 5 slides. The description for each virtual slide assigned is generally due at 1 pm on the third class day of the relevant unit. Descriptions should be submitted via the Sakai web site (Assignments tab) as a PowerPoint file.

Web site for virtual slides:https://pathology.oit.duke.edu/PATHOL750.html

Grading  
Exam 1 12%
Exam 2 12%
Exam 3 12%
Quizzes (open book, open note) 12%
Presentation 12%
Virtual Slide Descriptions 12%
Attendance & Participation 12%
Slide Practical Exam 16%

Exams will be combinations of questions or problems that illustrate the main topics studied to date and identification of pathologic processes exhibited in gross and/or microscopic images.  For the images, you will be expected to be able to identify the organs involved as well as the category of  pathologic process that is demonstrated (e.g. inflammatory/infectious/immunologic, hemodynamic/vascular, benign vs. malignant neoplasia, genetic/developmental, or environmental/nutritional). In some cases, you will also be expected to provide a diagnosis (i.e. acute inflammation in the lungs is pneumonia).

 

OVERALL GOALS AND OBJECTIVES 

To synthesize characteristics of disease processes based on etiology (cause) and pathogenesis (mechanism of expression).

To understand how disease processes affect physiological function (pathophysiology)

To trace pathologic processes from a molecular event to cellular alterations and to changes in organ function and appearance
  
To describe the size, shape, color, consistency, and location of gross anatomic abnormalities

To recognize and describe abnormal features of gross and microscopic specimens that ares common to all organ systems, and to categorize them into the 5 major pathologic processes:

  1. Inflammatory/Infectious/Immunologic
  2. Vascular/Hemodynamic
  3. Developmental/Genetic
  4. Neoplastic
  5. Environmental/Nutritional

To describe microscopic characteristics of individual cells (cytology) including their size, shape, and color (staining characteristics), and microscopic characteristics of groups of cells (architecture) and the relationships between individual cells and surrounding structures

To use the microscope to reinforce knowledge obtained from other sources

To distinguish preparation or fixation artifacts from abnormalities of disease

 

 

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