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The remaining chapters are organized into “Diseases of Organ Systems”, where manifestations of the various basic pathologic processes in various organ systems are described in greater detail. Portions of some of these additional chapters will also be required reading. The chapters that are not required may also be helpful for class and/or your research. Recorded Lectures and Quizzes: In previous years, this class met for 90 minutes/class session to provide adequate time for both lecture and laboratory. However, this year, our live virtual class meetings are restricted to 50 minutes. To make the best use of this limited “face time”, we will trying some new things. Most units have 3 class meetings. On the first meeting, we will outline some basic concepts of the unit as well as giving live examples of the specific pathologic processes to be covered. The remainder of the important material for that unit will be recorded for you to watch before the next class session. A short, open book, open note quiz testing your understanding of these concepts will be due prior to the 2nd class session of the unit. The second class session will be devoted primarily to a virtual microscopy laboratory session, with sharing of specific virtual slides that students find problematic. On the third class session, instructors will lead discussions based on commonly encountered research problems that require an understanding of the pathologic mechanisms presented in that unit. Students should also be prepared to present their slide description powerpoints (see below) to the class as time permits. Exams: Exams will be combinations of questions or problems that illustrate and synthesize the main topics studied to date, as well as identification of pathologic processes exhibited in gross and/or microscopic images. For the images and on the slide practical, you will be expected to be able to identify the organs involved as well as the category of pathologic process that is demonstrated (e.g. inflammatory/infectious/immunologic, hemodynamic/vascular, benign vs. malignant neoplasia, genetic/developmental, or environmental/nutritional). In some cases, you will also be expected to provide a diagnosis (i.e. acute inflammation in the lungs is called Presentation: This is a 20-minute oral presentation on the pathophysiology of a disease of your choice. The topic must be pre-approved by the course director. You should not present about a disease that is part of your graduate research or one that we will be covering in class. In addition to the oral presentation, you must also provide a (no more than) 2 page handout summarizing the important points of your presentation. The handout should not just be a copy of your PowerPoint slides! Rather, it should help your classmates remember the important points about the disease that you are discussing. The references used to prepare your presentation should also be provided and are not part of the 2 page limit. To get into the habit of proper attribution, any slides that contain figures that you did not assemble yourself (i.e. they were derived from a paper or from the web) should also be referenced. The proper way to reference a web site is to give the URL and the access date. Slide Description Powerpoints: For most units, each student will be assigned a virtual slide to describe. Descriptions should include a low-to-medium magnification photo of the piece of tissue with important features annotated, as well as higher magnification images as needed to demonstrate the pathologic changes. These descriptions will be submitted in the form of a Powerpoint file. The expected number of slides in the ppt file is 3-5; the maximum is 5 slides. The description for each virtual slide assigned is generally due at 1 pm on the third class day of the relevant unit. Descriptions should be submitted via the Sakai web site (Assignments tab) as a PowerPoint file. Web site for virtual slides:https://pathology.oit.duke.edu/PATHOL750.html
Exams will be combinations of questions or problems that illustrate the main topics studied to date and identification of pathologic processes exhibited in gross and/or microscopic images. For the images, you will be expected to be able to identify the organs involved as well as the category of pathologic process that is demonstrated (e.g. inflammatory/infectious/immunologic, hemodynamic/vascular, benign vs. malignant neoplasia, genetic/developmental, or environmental/nutritional). In some cases, you will also be expected to provide a diagnosis (i.e. acute inflammation in the lungs is pneumonia).
OVERALL GOALS AND OBJECTIVES To synthesize characteristics of disease processes based on etiology (cause) and pathogenesis (mechanism of expression). To understand how disease processes affect physiological function (pathophysiology) To trace pathologic processes from a molecular event to cellular alterations and to changes in organ function and appearance To recognize and describe abnormal features of gross and microscopic specimens that ares common to all organ systems, and to categorize them into the 5 major pathologic processes:
To describe microscopic characteristics of individual cells (cytology) including their size, shape, and color (staining characteristics), and microscopic characteristics of groups of cells (architecture) and the relationships between individual cells and surrounding structures To use the microscope to reinforce knowledge obtained from other sources To distinguish preparation or fixation artifacts from abnormalities of disease
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